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(2009) A longitudinal pro-gram for biomarker development in Parkinson’s disease: a feasi-bility study. Amyloidosis (in amyloidosis, there may be splenomegaly). The activation ofcholinergic receptors on the cell surface triggers an increasein the intracellular concentration of cyclic guanosine mono-phosphate (cGMP), which in turn facilitates smooth musclecontraction

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The simultaneous effect of the inde-pendent variable and parameter is called the interaction effect.